Voriconazole In situ Gel for Ocular Drug Delivery

Preparation and characterization of bear bile-loaded pH sensitive in-situ gel eye drops for ocular drug delivery

Objective(s): In this study, a stable bear bile-loaded pH sensitive in-situ eye drop gel was prepared for sustain delivery and enhanced therapeutic application. Materials and Methods: Bear bile-loaded in-situ ocular gels with different Carbopol/Hydroxypropyl methylcellulose (HPMC)  ratios were prepared and their stability was tested in P...

In-Situ Gel Formation for Ocular Drug Delivery System an Overview

Ophthalmic In-situ gels are viscous polymer‐based liquids that exhibit sol‐to‐gel phase transition on the ocular surface due to change in a specific physicochemical parameter like ionic strength, pH or temperature Gel dosage forms are successfully used as drug delivery systems considering their ability to prolong the drug release. To prolong the precorneal resident time and improve ocular bioav...

Hp-β-CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

The objective of the present study was to design ophthalmic delivery systems based on polymeric carriers that undergo sol-to-gel transition upon change in temperature or in the presence of cations so as to prolong the effect of HP- β -CD Voriconazole (VCZ) in situ gelling formulations. The in situ gelling formulations of Voriconazole were prepared by using pluronic F-127 (PF-127) or with combin...

Insitu Gel : a Novel System for Ocular Drug Delivery

Eye is the most vital organ of the body. To achieve effective ocular therapy, an adequate amount of active ingredients must be delivered and maintain at the site of action within the eye. The anatomical structure and the protective physiological process of the eye exert a formidable defense against ophthalmic drug delivery, leads to poor precorneal drug loss results in poor ocular by availabili...

in situ gelling systems for drug delivery